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Index > Protein center > Kcp(Gene name) > Mouse
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  • Kcp (Gene name),
  • Kielin/chordin-like protein (Protein name ),  KCP_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Kcp(Crim2;Kcp1);
    Protein name:
    Kielin/chordin-like protein;
    Alternative:
    Cysteine-rich motor neuron 2 protein(CRIM-2);Cysteine-rich BMP regulator 2;Kielin/chordin-like protein 1(KCP-1);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with BMP7 and, by doing so, enhances binding to the type I receptors that contains cytoplasmic serine-/threonine protein kinase domains. Also able to interact with activin-A and TGFB1.
    Function:
    Enhances bone morphogenetic protein (BMP) signaling in a paracrine manner. In contrast, it inhibits both the activin-A and TGFB1-mediated signaling pathways.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    1550
    Sequence:
    50:
    MAGARAALLP | LLLHLGSLAL | AARGGEVSRE | QPRLADAISQ | QQAPSHSLVP | 
    100:
    GETHQQQWCP | LEERLERLEA | EVTDLRKQNR | ELQARVVQLE | SCECWGPGHT | 
    150:
    CPEGARWEPD | ACTACVCRDG | TAHCGPQPNL | PHCRGCSHNG | QSYGHGETFS | 
    200:
    PDACTTCRCL | AGTVQCQGPS | CSELNCLESF | IPPGECCPIC | RPGCEYEGQL | 
    250:
    HQEGSSFLSS | SNPCLQCSCL | RSLVRCVPVK | CQPSPCLNPV | PRLGHCCPVC | 
    300:
    QASGCTEGNS | HRDHGQEWTT | PGDPCRICQC | LEGHIQCRQR | ECASLCPYPA | 
    350:
    RPLPGTCCPV | CDGCFLNGRE | HSSGEPVGSQ | DPCSSCRCTN | GSVQCEPLPC | 
    400:
    PPAPCRYPGR | IPGQCCPVCD | GCKYQGHEYR | SQETFTLQEN | GRCLRCVCQA | 
    450:
    GEVSCEEQDC | PVTPCVRSAS | GPQLCSACVL | NGEEFAEGIQ | WEPDDQPCTS | 
    500:
    CSCQDGVPVC | RAVLCSPVPC | QHPTQPPGAC | CPSCDSCTYH | SLVYANGQNF | 
    550:
    TDVDSPCQTC | YCEDGTVRCS | LINCPFTTCA | KPQNGPGQCC | PKCPDCILEA | 
    600:
    QVFVDGERFP | HPRDPCQECW | CQEGQAHCQL | RACPSAPCVH | PLPGTCCKND | 
    650:
    CTGCAFGGKE | YPNGADFPHP | TDPCRLCRCL | SGNVQCLARR | CPPLSCPQPV | 
    700:
    LTPGDCCPQC | PDAPADCPQS | GNMVPVRHQE | HFFQPGDPCS | RCLCLDGSVS | 
    750:
    CQRLTCPPAP | CAHPRRDACC | PSCDGCLYQG | KEFASGERFP | SPNVACHVCL | 
    800:
    CWEGSVKCEP | RTCAPAQCPF | PTREDCCPAC | DSCDYLGVSY | LSSQEFPDPR | 
    850:
    EACNLCTCLG | GFVTCTRRPC | EPPACSHPLI | VPEHCCPTCQ | GCLYHGITAA | 
    900:
    LGETLPDPLD | PTCSLCTCEE | GSMRCQKKPC | PPAPCAHPSP | GPCFCPVCRS | 
    950:
    CLSQGREHQD | GEEFEGPEGS | CERCRCLAGQ | VSCTRLQCPS | LPCLHQVTEP | 
    1000:
    GTCCPRCTGC | LARGEEHPEG | SSWVPADSPC | SSCMCHKGII | TCAQVQCVSA | 
    1050:
    CIWPQEGPSD | CCPQCSGCEH | GGRKYEPGES | FQPGADPCEV | CICKQKREGP | 
    1100:
    PSLHCSRRQC | PSLVGCPPSQ | LLPPGPQHCC | PTCAQALSNC | TEDLVGSELV | 
    1150:
    PPDPCYTCQC | QDLTWLCTHR | ACPELSCPLW | ERHTTPGSCC | PVCKDPTQSC | 
    1200:
    MHQGRWVASG | EQWAVDACTS | CSCVAGTVHC | QTQRCRKLAC | SRDEVPALSP | 
    1250:
    GSCCLRCLPR | PASCMAFGDP | HYRTFDGRLL | HFQGSCSYVL | AKDCHGEDFS | 
    1300:
    VHVTNDDRGR | RGVAWTQEVA | VLLGTVAVRL | LQGRTVMVDQ | HTVTLPFLRE | 
    1350:
    PLLYIELRGH | TVILHAQPGL | QVLWDGQSQV | EVRVPSSYRG | QTCGLCGNFN | 
    1400:
    GFAQDDLQGP | DGRLLPTEAS | FGNSWKVPKG | LGPGRPCSAG | REVDPCRAAG | 
    1450:
    YRARREANAR | CGILKTSPFS | HCHAVVPPEP | FFAACVYDLC | ACGPGSSSDT | 
    1500:
    CLCDALEAYA | SHCRQAGVTP | VWRGPTLCVV | GCPVDRGFVF | DECGPPCPRT | 
    1550:
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    Pfam:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Kielin/chordin-like protein
    Cat.:
    E1062h
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse Kielin/chordin-like protein
    Cat.:
    E1062m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Kielin/chordin-like protein
    Cat.:
    U1062m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Kielin/chordin-like protein
    Cat.:
    U1062h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse Kielin/chordin-like protein
    Cat.:
    P1062Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Kielin/chordin-like protein
    Cat.:
    P1062Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse Kielin/chordin-like protein
    Monoclonal Antibody for Mouse Kielin/chordin-like protein
    Protein for Mouse Kielin/chordin-like protein
    Protein for Mouse Kielin/chordin-like protein

    R&D Technical Data
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    Precision
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Kielin/chordin-like protein, a novel enhancer of BMP signaling, attenuates renal fibrotic disease."
      Lin J. , Patel S.R. , Cheng X. , Cho E.A. , Levitan I. , Ullenbruch M. , Phan S.H. , Park J.M. , Dressler G.R.
      Nat. Med.11:387-393(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);FUNCTION;INTERACTION WITH BMP7;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE;SUBCELLULAR LOCATION;INDUCTION BY RENAL STRESSES
      strain: FVB/N.
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      strain: NOD.
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    4. 4.
      "The cysteine-rich domain protein KCP is a suppressor of transforming growth factor beta/activin signaling in renal epithelia."
      Lin J. , Patel S.R. , Wang M. , Dressler G.R.
      Mol. Cell. Biol.26:4577-4585(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ACTIVIN A AND TGFB1
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